Molecular and Translational Toxicology (MATT)

 
Date
Title
Lecturer
Content
1 9/4 Basic Concepts in Translational Toxicology  Vishal S. Vaidya Overview, Definitions, Importance in drug development, environmental health and patient care, fundamental concepts, techniques used.
2  9/9 Pharmacodynamics David Golan Drug receptor interactions, agonists, antagonists, pharmacogenomics
3 9/11 Pharmacokinetics David Golan Absorption, Distribution, Metabolism, Excretion
4 9/16 Biology of the Normal vs Abnormal Cell Jagesh V. Shah Structure/function of cell and cellular components, Mitochondria, ER & Nucleus as targets of Toxicants
5  9/18 Biotransformation Sujal Deshmukh Bioactivation, Detoxification, Factors affecting susceptibility
6 9/23 Genetic Toxicity & Carcinogenesis Alan D'Andrea DNA damage, Mutation, DNA repair, Initiation & Progression in Carcinogenesis
7  9/25 Epigenetics and Toxicology
 Bernardo Lemos
 Definition, Methylation, Histone Modifications, Non Coding RNA, Genomic Imprinting
  9/30 EXAM 1 
8  10/2 Brain Toxicology Francisco Quintana
  • Organ Structure Function
  • Incidence and Types of damage
  • Examples of Toxic agents causing damage
  • Biomarkers (Traditional and Novel)    
9 10/7 Lung Toxicology David Christiani
10  10/9 Liver Toxicology Vishal Vaidya
  10/14 COLUMBUS DAY
11 10/16 Nano Toxicology Philip Demokritou
12  10/21 Pesticides Alan Woolf
13  10/23 Heart Toxicology James Januzzi
14 10/28 Metal Toxicology Marc Weisskopf  
15 10/30 Endocrine Disruptors Joseph Braun  
16 11/4 Kidney Toxicology   Oana Nicoara  
17  11/6 Drugs of Abuse Chris Rosenbaum and Rick Church
  • Type of agents
  • Mechanisms of Toxicity
  • Antidotes    
  11/11 VETERANS DAY

11/13 EXAM 11
17 11/18 Toxicology in Therapeutic Development Nicole Hurst & Paul Nugent
18 11/20  Toxicity Monitoring Post Marketing Jerry Avorn
19 11/25 Mitigation of Toxicity Eva Guinan  Example of drug effective against radiation toxicity
20  11/27 Stem Cells for Toxicity Screening Benjamin Freedman  ES cells, iPS cells, Directed Differentiation, Protocols, Toxicology Application
21 12/2 Translational Technologies for Toxicology Anthony Bahinski  Organs on a Chip, Principles, Challenges and Applications
22 12/4 Zebrafish an Integrative Model for Toxicity Screening  Wolfram Goessling
 

12/9
12/11
12/16
12/18 

 Grant Writing, Review and Defense