Publications

Research Investigations

  1. Apte UM, Limaye PB, Ramaiah SK, Vaidya VS, Bucci TJ, Warbritton A, Mehendale HM. Upregulated promitogenic signaling via cytokines and growth factors: potential mechanism of robust liver tissue repair in calorie-restricted rats upon toxic challenge. Toxicol Sci. 2002;69(2):448-59.
  2. Anand SS, Soni MG, Vaidya VS, Murthy SN, Mumtaz MM, Mehendale HM. Extent and timeliness of tissue repair determines the dose-related hepatotoxicity of chloroform. Int J Toxicol. 2003;22(1):25-33.
  3. Vaidya VS, Shankar K, Lock EA, Bucci TJ, Mehendale HM. Renal injury and repair following S-1, 2 dichlorovinyl-L-cysteine administration to mice. Toxicol Appl Pharmacol. 2003;188(2):110-21.
  4. Shankar K, Vaidya VS, Wang T, Bucci TJ, Mehendale HM. Streptozotocin-induced diabetic mice are resistant to lethal effects of thioacetamide hepatotoxicity. Toxicol Appl Pharmacol. 2003;188(2):122-34.
  5. Shankar K, Vaidya VS, Apte UM, Manautou JE, Ronis MJ, Bucci TJ, Mehendale HM. Type 1 diabetic mice are protected from acetaminophen hepatotoxicity. Toxicol Sci. 2003;73(2):220-34.
  6. Vaidya VS, Shankar K, Lock EA, Bucci TJ, Mehendale HM. Role of tissue repair in survival from s-(1,2-dichlorovinyl)-L-cysteine-induced acute renal tubular necrosis in the mouse. Toxicol Sci. 2003;74(1):215-27.
  7. Anand SS, Murthy SN, Vaidya VS, Mumtaz MM, Mehendale HM. Tissue repair plays pivotal role in final outcome of liver injury following chloroform and allyl alcohol binary mixture. Food Chem Toxicol. 2003;41(8):1123-32.
  8. Shankar K, Vaidya VS, Corton JC, Bucci TJ, Liu J, Waalkes MP, Mehendale HM. Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity. FASEB J. 2003;17(12):1748-50.
  9. Vaidya VS, Shankar K, Lock EA, Dixon D, Mehendale HM. Molecular mechanisms of renal tissue repair in survival from acute renal tubule necrosis: role of ERK1/2 pathway. Toxicol Pathol. 2003;31(6):604-18.
  10. Vaidya VS, Ramirez V, Ichimura T, Bobadilla NA, and Bonventre JV. Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury. Am J Physiol Renal Physiol. 2006;290(2):F517-F529.
  11. van Timmeren MM, Bakker SJ, Vaidya VS, Bailly V, Schuurs TA, Damman J, Stegeman CA, Bonventre JV, and van Goor H. Tubular Kidney Injuring Molecule-1 (KIM-1) In Protein-Overload Nephropathy. Am J Physiol Renal Physiol. 2006;291(2):F456-F464.
  12. Duffield JS, Hong S, Vaidya VS, Lu Y, Fredman G, Serhan CN, Bonventre JV. Resolvin D series and Protrectin D1 mitigate acute kidney injury. Journal of Immunology. 2006;177:5902-5911.
  13. Perez-Rojas J, Blanco JA, Cruz C, Trujillo J, Vaidya VS, Uribe N, Bonventre JV, Gamba G, and Bobadilla NA. Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity. Am J Physiol Renal Physiol . 2007;292(1):F131-F139.
  14. de Borst MH, van Timmeren MM, Vaidya VS, van Dalen MB, Kramer AB, Schuurs TA, Bonventre JV, Navis G, and van Goor H. Induction of Kidney injury molecule-1 (Kim-1) in homozygous Ren2 rats is attenuated by blockade of the renin-angiotensin system or p38 MAP kinase. Am J Physiol Renal Physiol. 2007;292(1):F313-F320.
  15. Liangos O, Perianayagam MC, Vaidya VS, Han WK, Wald R, Tighiouart H, MacKinnon RW, Li L, Balakrishnan VS, Pereira BJG, Bonventre JV, Jaber BL. Urinary N-acetyl- -(D)-Glucosaminidase Activity and Kidney Injury Molecule-1 Level are Associated with Adverse Outcomes in Acute Renal Failure. JASN. 2007;18(3):904-912.
  16. Chen G, Bridenbaugh EA, Akintola AD, Catania JM, Vaidya VS, Bonventre JV, Dearman AC, Sampson HW, Zawieja DC, Burghardt RC, Parrish AR. Increased Susceptibility of Aging Kidney to Ischemic Injury: Identification of Candidate Genes Changed During Aging, but Corrected by Caloric Restriction. Am J Physiol Renal Physiol. 2007;293(4):F1272-1281.
  17. Prozialeck WC, Vaidya VS, Liu J, Waalkes MP, Edwards JR, Lamar PC, Bernard AM, Dumont X and Bonventre JV. Kidney Injury Molecule-1 (Kim-1) as an Early Biomarker of Cadmium Nephrotoxicity. Kidney International. 2007;72(8):985-993.
  18. Espandiari P, Zhang J, Rosenzweig B, Vaidya VS, Sun J, Schnackenberg L, Herman E, Knapton A, Bonventre JV, Beger R, Thompson K, Hanig J. The Utility of a Rodent Model in Detecting Pediatric Drug-induced Nephrotoxicity. Toxicological Sciences. 2007;99(2):637-648.
  19. van Timmeren MM, Vaidya VS, van Ree RM, Oterdoom LH, de Vries AP, Gans OB, van Goor H, Stegeman OA, Bonventre JV, Bakker JL. High urinary excretion of Kidney Injury Molecule-1 (KIM-1) is an independent predictor of graft loss in renal transplant recipients. Transplantation. 2007;84(12):1625-1630.
  20. Zhou Y, Vaidya VS, Brown RP, Rosenzweig BA, Thompson KL, Zhang J, Miller TJ, Bonventre JV, Goering PL. Comparison of Kidney Injury Molecule-1 and Other Nephrotoxicity Biomarkers in Urine and Kidney Following Acute Exposure to Gentamicin, Mercury, and Chromium. Toxicological Sciences. 2008;101(1):159-170.
  21. Zhang J, Brown RP, Shaw M, Vaidya VS, Zhou Y, et al. 2008. Immunolocalization of Kim-1, RPA-1, and RPA-2 in Kidney of Gentamicin-, Mercury-, or Chromium-Treated Rats: Relationship to Renal Distributions of iNOS and Nitrotyrosine. Toxicol. Pathol. 2008;36(3):397-409.
  22. Vaidya VS*, Waikar SS*, Ferguson MA, Collings FB, Sunderland K, Gioules, C, Bradwin G, Matsouaka R, Betensky RA, Curhan G, and Bonventre JV. Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans. Clinical and Translational Science 2008; 1(3):200-208. * Co first author
  23. Trujillo J, Cruz C, Tovar AR, Vaidya VS, Zambrano E, Bonventre JV, Gamba G, Torres N, Bobadilla NA. Renoprotective mechanisms of soy protein intake in the obese zucker rat. Am J Physiol Renal Physiol. 2008;295:F1574-1582.
  24. Chagon F, Vaidya VS, Plante GE, Bonventre JV, Bernard A, Guindi C, Lesur O. Modulation of AQP-2/V2R kidney expression and tubular injury following endotoxin (LPS) challenge. Critical Care Medicine. 2008;36(11):3054-3061.
  25. Waanders F, Vaidya VS, Goor HV, Leuvenink H, Damman K, Hamming I, Bonventre JV, Vogt L, Navis G. Effect of renin-angiotensin-aldosterone system inhibition, dietary sodium restriction, and/or diuretics on urinary kidney injury molecule 1 excretion in nondiabetic proteinuric kidney disease: a post hoc analysis of a randomized controlled trial. Am J Kidney Dis. 2009;53(1):16-25.
  26. Kramer AB,van Timmeren MM, Schuurs TA, Vaidya VS, Bonventre JV, van Goor H, Navis G. Reduction of proteinuria in adriamycin-induced nephropathy is associated with reduction of renal Kidney injury molecule-1 (Kim-1) over time. Am J Physiol Renal Physiol. 2009;296: F1136-F1145.
  27. Vaidya VS, Ford GF, Waikar SS, Wang Y, Clement M, Ramirez V, Glaab WE, Troth SP, Sistare FD, Prozialeck WC, Edwards JR, Bobadilla NA, Mefferd S, Bonventre JV. RenaStick: A Rapid Urine Test for Early Detection of Kidney Injury. Kidney Int. 2009;76(1):108-114. 
    Press Release: 1) “Urine test for kidney disease” Nature Press Release. 2) “New Life-Saving Test to Detect Kidney Injury” CIMIT Press Release. 
    Commentary: Parikh CR, A point-of-care device for acute kidney injury: a fantastic, futuristic, or frivolous 'measure'? Kidney Int. 2009 Jul;76(1):8-10. 
  28. Sieber M, Hoffmann D, Adler M, Vaidya VS, Clement M, Bonventre JV, Zidek N, Rached E, Amberg A, Callanan JJ, Dekant W, Mally A. Comparative analysis of novel noninvasive renal biomarkers and metabonomic changes in a rat model of gentamicin nephrotoxicity. Toxicol Sci. 2009;109(2):336-349. 
  29. Prozialeck WC, Edwards JR, Vaidya VS, Bonventre JV. Preclinical Evaluation of Novel Urinary Biomarkers of Cadmium Nephrotoxicity. Toxicol Appl Pharmacol. 2009;238(5):301-305.
  30. Prozialeck WC, Edwards JR, Lamar PC, Liu J, Waalkes MP, Vaidya VS, Bonventre JV. Expression of kidney injury molecule-1 (Kim-1) in relation to necrosis and apoptosis during the early stages of Cd-induced proximal tubule injury. Toxicol Appl Pharmacol. 2009;238(5):306-314.
  31. Nijboer WN, Schuurs TA, Damman J, van Goor H, Vaidya VS, van der Heide JJ, Leuvenink HG, Bonventre JV, Ploeg RJ. Kidney Injury Molecule-1 is an Early Noninvasive Indicator for Donor Brain Death-Induced Injury Prior to Kidney Transplantation. Am J Transplant. 2009;9(8):1752-1759.
  32. Zhang J, Goering PL, Espandiari P, Shaw M, Bonventre JV, Vaidya VS, Brown RP, Keenan J, Kilty CG, Sadrieh N, Hanih JP. Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin, cisplatin-, and valproic acid treated rats: potential role of iNOS and nitrotyrosine. Toxicol. Pathol. 2009;37(5):629-643.
  33. Espandiari P, Rosenzweig B, Zhang J, Zhou Y, Schnackenberg L, Vaidya VS, Goering PL, Brown RP, Bonventre JV, Mahjoob K, Holland RD, Beger RD, Thompson K, Hanig J, Sadrieh N. Age-related differences in susceptibility to cisplatin-induced renal toxicity.  J Appl Toxicol. 2009:30(2):172-182.
  34. Ferguson MA, Vaidya VS, Waikar SS, Collings FB, Sunderland K, Gioules C, Bonventre JV. Urinary Liver-Type Fatty Acid Binding Protein is Predictive of Adverse Outcomes in Acute Kidney Injury. Kidney Int.  2010:77(8):708-714.
  35. Hoffmann D, Adler M, Vaidya VS, Rached E, Mulrane L, Gallagher WM, Callanan JJ, Gautier JC, Matheis K, Staedtler F, Dieterle F, Brandenburg A, Sposny A, Hewitt P, Ellinger-Ziegelbauer H, Bonventre JV, Dekant W, Mally A. Performance of novel kidney biomarkers in preclinical toxicity studies. Tox. Sci. 2010:116(1):8-22.
  36. Vaidya VS,Ozer JS, Dieterle F, Collings FB, Ramirez V, Troth S, Muniappa N, Thudium D, Gerhold D, Holder D, Bobadilla NA, Marrer E, Perentes E, Cordier A, Vonderscher J, Maurer G, Goering PL, Sistare F and Bonventre JV. Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in a preclinical biomarker qualification studies. Nat. Biotechnol. 2010:28(5);478-485. 
    Press Release: 1) “New Kidney Injury Biomarker” Environmental Factor (NIEHS news letter), July 2010. 2) “Brigham Renal Division Research at the Center of an International Effort to Identify Next Generation Biomarkers to Screen Kidney Toxicity” BWH News Release. 3) “Biomarkers for kidney damage should speed drug development” Brendan Borrell (Published online 10 May 2010 | Nature | doi:10.1038/news.2010.232).
  37. Damman K, Van Veldhuisen DJ, Navis G, Vaidya VS, Smilde TD, Westenbrink BD, Bonventre JV, Voors AA, Hillege HL. Tubular damage in chronic systolic heart failure is associated with reduced survival independent of glomerular filtration rate. Heart 2010:96)16);1297-1302.
  38. Krishnamoorthy A, Clement ME, O’Leary E, Bonventre JV, Vaidya, VS. TIM2 gene deletion results in susceptibility to cisplatin induced kidney toxicity. Tox Sci. 2010:118(1):298-306.
  39. Koyner JL, Vaidya VS, Bennett MR, Ma Q, Worcester E, Akhter SA, Raman, J, Jeevanandam V, O’Connor MF, Devarajan P, Bonventre JV, Murray PT. Urinary Biomarkers in the Clinical Prognosis and Early Detection of Acute Kidney Injury. CJASN 2010:118(1);298-306.
  40. Vaidya VS*, Niewczas, MA*, Ficociello LH, Johnson A, Collings FB, Warram JH, Krolewski AS, Bonventre, JV. Urinary Tubular Injury Biomarkers, KIM-1 and NAG, Predict Regression of Microalbuminuria In Type 1 Diabetes. Kidney Int. 2011:79(4):464-470.* Co first author.
  41. Endre ZH, Pickering JW, Walker RJ, Devarajan P, Edelstein CL, Bonventre JV, Frampton CM, Bennett MR, Ma Q, Sabbisetti VS, Vaidya VS, Walcher AM, Shaw GM, Henderson SJ, Nejat M, Schollum JB, George PM. Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function. Kidney Int. 2011: 79(10):1119-1130.
  42. Krishnamoorthy A, Ajay AK, Hoffmann D, Kim T, Ramirez V, Campanholle G, Bobadilla NA, Waikar SS, Vaidya VS. Fibrinogen β-derived Bβ15-42 peptide protects against kidney ischemia/reperfusion injury. Blood, 2011:118(7):1934-1942.
  43. Kim T, Ramirez V, Barrera-Chimal J, Bobadilla NA, Park PJ, Vaidya VS. Gene expression analysis reveals the cell cycle and kinetochore genes participating in renal ischemia reperfusion injury and early development in kidney. PLoS ONE, 2011: 6(9): e25679.

Peer-reviewed review articles

  1. Vaidya VS, Bonventre JV. Mechanistic Biomarkers for Cytotoxic Acute Kidney Injury.In: Expert Opinions on Drug metabolism and Toxicology. London, UK: Ashley Publications; 2006;2(5):697-713.
  2. Vaidya VS, Ferguson MA, Bonventre JV. Biomarkers of acute kidney injury. Annual Reviews of Pharmacology and Toxicology. 2008;48:463-493.
  3. Collings FB, Vaidya VS. Novel technologies for the discovery and quantitation of biomarkers of toxicity. Toxicology. 2008;245(3):167-174.
  4. Ferguson MA, Vaidya VS, Bonventre JV. Biomarkers of nephrotoxic acute kidney injury. Toxicology. 2008;245(3):182-193.
  5. Bonventre JV, Vaidya VS, Schmouder R, Feig P, Dieterle F. Next-generation biomarkers for detecting kidney toxicity. Nat. Biotechnol. 2010:28(5);436-440.
  6. El-Sabbahy, M, Vaidya, VS. Ischemic kidney injury and mechanisms of tissue repair. Wiley Interdisciplinary Reviews Systems Biology Medicine, 2010 Dec 31. [Epub ahead of print]. 

Reviews/Chapters/Editorials

  1. Apte UM, Shankar K, Vaidya VS, Limaye PB, Sawant SP. Principles and Methods of Toxicology, By Wallace Hayes, 2000 (Book Review). In: Int. J. Toxicol. Taylor and Francis Inc.;2001. p. 333.
  2. Vaidya VS, Shankar K, Apte UM, Sawant SP, Limaye PB, Mehendale HM. Introduction to Biochemical Toxicology, By Ernest Hodgson and Robert C. Smart, 2001 (Book Review). In: Int. J. Toxicol. New York (NY): John Wiley & Sons, Inc.;2001. p. 331.
  3. Vaidya VS, Mehendale HM. Ephedra. In: Encyclopedia of Toxicology, by Philip Wexler. Oxford: Elsevier;2005. p. 223-228.
  4. Vaidya VS, Nicholson JK, Mehendale HM. Metabonomics. In: Encyclopedia of Toxicology, by Philip Wexler. Oxford: Elsevier;2005. p. 41-46.
  5. Vaidya VS, Mehendale HM. Mercuric chloride. In: Encyclopedia of Toxicology, by Philip Wexler. Oxford: Elsevier;2005. p. 33-36.
  6. Vaidya VS, Mehendale HM. S-(1,2-dichlorovinyl)-L-cysteine. In: Encyclopedia of Toxicology, by Philip Wexler. Oxford, UK: Elsevier;2005. p. 747-750.
  7. Sheridan AM, Vaidya VS, Mehendale HM. Cell cycle. In: Encyclopedia of Toxicology, by Philip Wexler. Oxford: Elsevier;2005. p. 490-495.
  8. Ferguson MA, Vaidya VS, and Bonventre JV. Biomarkers in acute kidney injury. In: M.H. Rosner MH and Okusa MD editors. Biomarkers in Renal Disease. New York: Nova Science Publishers, Inc; 2008. 43-74. 
  9. Vaidya VS, Ferguson MA, Bonventre JV. Biomarkers of acute kidney injury. In: Schnellmann RG editor. Comprehensive Toxicology: Renal Toxicology. Oxford, UK: Elsevier. 2010; p. 197-211.
  10. Ferguson, MA, Vaidya, VS. Biomarkers: An Evolutionary Perspective. In: Vaidya VS and Bonventre JV editors. Biomarkers: In Medicine, Drug Discovery, and Environmental Health.  Hoboken, NJ: John Wiley & Sons, Inc., 2010, p 1-4.

Educational Material for patients and the lay community

Book

/public/images/0470452242.jpgVaidya VS, Bonventre JV. Biomarkers: In Medicine, Drug Discovery and Environmental Health. Hoboken, NJ: John Wiley & Sons Inc; 2010. 


Thesis